Renee Zellweger is re-teaming with her Chicago producers to executive produce an original movie for Lifetime that will raise awareness for breast cancer issues, reports Reuters.

Living Proof tells the true story of Denny Slamon (Harry Connick Jr.), a UCLA doctor who developed the breast cancer drug Herceptin 2, and his relentless battle to keep the drug trials afloat and save the lives of thousands of women.

“The whole goal of this movie is to bring even greater awareness to the problem that women face with breast cancer and to create this very high-profile event,” said Neil Meron, executive producer.

Living Proof is set to air in October as the “programming centerpiece” of Lifetime’s 14th annual public awareness campaign “Stop Breast Cancer for Life.”

Renee Zellweger and George Clooney do a little two-step as they attend the Premiere of Jeux de Dupes on Friday in Paris, France.

Earlier today George’s girlfriend Sarah Larson spilled the beans on how she met her dashing man.

20+ pictures of George Clooney and Renee Zellweger doing a little dance at a premiere… More Here! »

George Clooney and Renee Zellweger celebrate at the Leatherheads premiere after party at Automat restaurant in London, England on Tuesday.

The dashing pair walked the red carpet yesterday as well.

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Renee Zellweger (in Marchesa) arrives at the European premiere of her new film Leatherheads at the Odeon Leicester Square on Tuesday in London, England.

The 38-year-old actress wore a beautiful plum-colored Marchesa dress and gold strappy heels.

Hopefully Leatherheads performs better at the box office in England than it did here in the States!

65+ pictures inside of Renee Zellweger looking pretty in plum… More Here! »

Renee Zellweger leaves her Manhattan hotel and arrives at the Ed Sullivan Theatre for the Late Show With David Letterman on Monday to promote her new movie Leatherheads.

So far, the film has garnered an average 54% on RottenTomatoes.com. Here’s what some of the top critics had to say:

“Leatherheads labors so strenuously to approximate some of the old screwball spirit of the ’30s and ’40s that it winds up in traction.” — The New York Times

“Reproducing a period-piece screwball comedy for a modern audience turns out to be one playful, self-deprecating wink too many for [Clooney].” — Entertainment Weekly

“Disappointing period football comedy laterals too often without a clear goal in mind.” — Hollywood Reporter

“Aims only to please and proves perfectly amiable, but ultimate effect is one of much energy expended to minimal payoff. ” — Variety

15+ pictures inside of Renee Zellweger @ Late Show with David Letterman… More Here! »

Renee Zellweger arrives at the world premiere of Leatherheads in Los Angeles on Monday.

Renee, 38, stars as sassy newspaperwoman Lexie Littleton alongside John Krasinski’s character, Carter Rutherford.

Krasinski, 28, shared about how his Oscar-winning co-star welcomed and calmed him down when he first arrived on set.

“On my first day filming, I was terrified. Renee immediately saw that and she calmed me down by getting me to talk - because I wasn’t breathing very well,” Krasinski said. “They always remember their first day and that’s what makes them great stars.”

50+ pics of Renee and her co-stars arriving at the premiere…
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George Clooney and Renee Zellweger talk to a crowd of over 500 fans at the Westin Poinsett Hotel during the final stop on their “Leatherheads Whistle Stop Express” on Thursday in Greenville, South Carolina.

The costars, who were inducted as honorary citizens of Greenville, later talked with media about their football flick, out next Friday, April 4.

“We were fairly aware of Greenville before we came here,” Clooney said. “We had a great time being here. We couldn’t have done it without you.”

Added Renee, “Thanks again for the warm welcome. We had the time of our lives. I have a lot of friends from the Carolinas, so I knew how beautiful it was, and I knew I would have a good time, and I knew I would eat really well.”

Smart move to ditch the newsboy cap, Georgie!

35+ pictures inside of honorary citizens George Clooney and Renee Zellweger… More Here! »

George Clooney continues to rock out his old-fashioned newsboy cap as he promotes his new film Leatherheads at the Historic Salisbury Station on Wednesday in Salisbury, North Carolina.

Costar Renee Zellweger, 38, joined George, 46, in Salisbury, which was the third stop on the “Whistle Stop Express” tour.

Leatherheads opens in theaters nationwide next Friday, April 4. It’s the first project produced by Smoke House, Clooney’s newly formed production company with Good Night and Good Luck partner Grant Heslov. The Office’s John Krasinski also stars in the film.

15+ pictures inside of newsboy-cap-clad George Clooney… More Here! »